【歯周病Tips!】の参考文献一覧 まとめ

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オーラルデントの有効成分と口臭予防・抑制メカニズム

  • Milk Science, 64(2), 2015

ココナッツオイルで虫歯や歯肉炎になりにくいって知ってた?

  1. Fatty Acids and Derivatives as Antimicrobial Agents(Antimicrob Agents Chemother. 1972 Jul; 2(1): 23–28.)

  2. The Properties of Lauric Acid and Their Significance in Coconut Oil(Journal of the American Oil Chemists’ SocietyVolume 92, Issue 1, pp 1–15)

  3. Fatty Acids and Derivatives as Antimicrobial Agents(Antimicrob Agents Chemother. 1972 Jul; 2(1): 23–28.)

  4. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms(Arch Oral Biol. 2011 Jul; 56(7): 650–654.)

  5. Effect of coconut oil in plaque related gingivitis – A preliminary report.(Niger Med J. 2015 Mar-Apr;56(2):143-7.)
  6. Effect of oil gum massage therapy on common pathogenic oral microorganisms – A randomized controlled trial(J Indian Soc Periodontol. 2014 Jul-Aug; 18(4): 441–446.)

  7. Comparison of Antimicrobial Activity of Chlorhexidine, Coconut Oil, Probiotics, and Ketoconazole on Candida albicans Isolated in Children with Early Childhood Caries: An In Vitro Study(Scientifica (Cairo). 2016; 2016: 7061587.)

  8. The Effect of Coconut Oil pulling on Streptococcus mutans Count in Saliva in Comparison with Chlorhexidine Mouthwash.(J Contemp Dent Pract. 2016 Jan 1;17(1):38-41.)

新しい審美歯科療法『ピンホールテクニック』をレビュー!

  • John C. Chao et al.(J Periodontol Vol.32 November 5 2012). A Novel Approach to Root Coverage: The Pinhole Surgical Technique

フードピラミッドのススメ【今日から使える!】

  1. Walter C. Willett; P. J. Skerrett (2001-07-31). Eat, Drink, and Be Healthy: The Harvard Medical School Guide to Healthy Eating. Free Press. ISBN 0-684-86337-5.
  2. Dental Health Foundation web site(http://www.dentalhealth.ie)

ケトジェニックダイエット・ビギナーズガイド【永久保存版】

  1. The ketogenic diet: one decade later.(Pediatrics. 2007 Mar;119(3):535-43.)
  2. The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on glycemic control in type 2 diabetes mellitus(Nutr Metab (Lond). 2008; 5: 36.)

  3. The ketogenic diet: a 3- to 6-year follow-up of 150 children enrolled prospectively.(Pediatrics. 2001 Oct;108(4):898-905.)
  4. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer(Nutr Metab (Lond). 2007; 4: 5.)

  5. Neuroprotective and disease-modifying effects of the ketogenic diet(Behav Pharmacol. 2006 Sep; 17(5-6): 431–439.)

  6. A review of low-carbohydrate ketogenic diets.(Curr Atheroscler Rep. 2003 Nov;5(6):476-83.)
  7. The human metabolic response to chronic ketosis without caloric restriction: preservation of submaximal exercise capability with reduced carbohydrate oxidation.(Metabolism. 1983 Aug;32(8):769-76.)
  8. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.(Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243-51.)
  9. The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism.(Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):309-19.)
  10. Diet and Syndrome X.(Curr Atheroscler Rep. 2000 Nov;2(6):503-7.)
  11. Insulin stimulation of hepatic triacylglycerol secretion in the insulin-replete state: implications for the etiology of peripheral insulin resistance.(Ann N Y Acad Sci. 2002 Jun;967:52-65.)
  12. Very-low-carbohydrate diets and preservation of muscle mass(Nutr Metab (Lond). 2006; 3: 9.)

  13. Composition of weight lost during short-term weight reduction. Metabolic responses of obese subjects to starvation and low-calorie ketogenic and nonketogenic diets.(J Clin Invest. 1976 Sep; 58(3): 722–730.)

  14. Ketosis and appetite-mediating nutrients and hormones after weight loss.(Eur J Clin Nutr. 2013 Jul;67(7):759-64.)
  15. The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review.(J Am Coll Nutr. 2004 Oct;23(5):373-85.)
  16. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum.(Am J Clin Nutr. 2008 Jan;87(1):44-55.)
  17. A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women.(J Clin Endocrinol Metab. 2003 Apr;88(4):1617-23.)
  18. A low-carbohydrate diet is more effective in reducing body weight than healthy eating in both diabetic and non-diabetic subjects.(Diabet Med. 2007 Dec;24(12):1430-5.)
  19. Dietary protein, weight loss, and weight maintenance.(Annu Rev Nutr. 2009;29:21-41.)
  20. Thermodynamics of weight loss diets.(Nutr Metab (Lond). 2004 Dec 8;1(1):15.)
  21. Ketones suppress brain glucose consumption.(Adv Exp Med Biol. 2009;645:301-6.)
  22. The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.(Annu Rev Nutr. 2010 Aug 21;30:273-90.)
  23. Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet.(Am J Clin Nutr. 2009 Sep;90(3):519-26.)
  24. Fuel metabolism in starvation.(Annu Rev Nutr. 2006;26:1-22.)
  25. Medium term effects of a ketogenic diet and a Mediterranean diet on resting energy expenditure and respiratory ratio(BMC Proc. 2012; 6(Suppl 3): P37.)

  26. Nonequilibrium thermodynamics and energy efficiency in weight loss diets.(Theor Biol Med Model. 2007 Jul 30;4:27.)
  27. About diabetes(WHO website)

  28. A low-carbohydrate, ketogenic diet to treat type 2 diabetes.(Nutr Metab (Lond). 2005 Dec 1;2:34.)
  29. Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes.(Ann Intern Med. 2005 Mar 15;142(6):403-11.)
  30. Nitrogen metabolism and insulin requirements in obese diabetic adults on a protein-sparing modified fast.(Diabetes. 1976 Jun;25(6):494-504.)
  31. Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus.(Diabetes. 1986 Sep;35(9):990-8.)
  32. Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat/low-calorie diets in the management of obesity and its comorbidities.(Obes Rev. 2009 Jan;10(1):36-50.)
  33. Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors.(Obes Rev. 2012 Nov;13(11):1048-66.)
  34. Mitochondria: The ketogenic diet–A metabolism-based therapy.(Int J Biochem Cell Biol. 2015 Jun;63:55-9.)
  35. The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.(Nutr Metab (Lond). 2007 Feb 21;4:5.)
  36. Calorie or carbohydrate restriction? The ketogenic diet as another option for supportive cancer treatment.(Oncologist. 2013;18(9):1056.)
  37. [Anticonvulsant and neuroprotective effects of the ketogenic diet].(Przegl Lek. 2010;67(3):205-12.)
  38. The biochemistry of ketogenesis and its role in weight management, neurological disease and oxidative stress.(J Physiol Biochem. 2012 Mar;68(1):141-51.)
  39. Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.(Neurology. 2006 Feb 28;66(4):617; author reply 617.)
  40. The effects of a low-carbohydrate, ketogenic diet on the polycystic ovary syndrome: A pilot study(Nutr Metab (Lond). 2005; 2: 35.)

  41. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.(J Neurosci Res. 2005 Nov 1;82(3):413-20.)
  42. Nutrition and acne: therapeutic potential of ketogenic diets.(Skin Pharmacol Physiol. 2012;25(3):111-7.)

『ザク豆腐』を食べて癌や心臓病のリスクを低減させよう!

  1. An overview of the last 10 years of genetically engineered crop safety research.(Crit Rev Biotechnol. 2014 Mar;34(1):77-88.)
  2. Effect of sprouting of soybean on the chemical composition and quality of soymilk and tofu.(J Food Sci Technol. 2014 May;51(5):915-21.)
  3. Isoflavones in retail and institutional soy foods.(J Agric Food Chem. 1999 Jul;47(7):2697-704.)
  4. Nutritional quality of legumes, and their role in cardiometabolic risk prevention: a review.(J Med Food. 2013 Mar;16(3):185-98.)
  5. Exposure to isoflavone-containing soy products and endothelial function: a Bayesian meta-analysis of randomized controlled trials.(Nutr Metab Cardiovasc Dis. 2012 Mar;22(3):182-91.)
  6. Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke.(Eur Heart J. 2008 Nov;29(22):2800-7.)
  7. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women.(Am J Clin Nutr. 2002 Aug;76(2):365-72.)
  8. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women.(J Nutr. 2001 Apr;131(4):1202-6.)
  9. Soy Protein, Saponins and Plasma Cholesterol(J. Nutr. November 1, 2001 vol. 131 no. 11 2971)
  10. Soyasaponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters.(Exp Biol Med (Maywood). 2005 Jul;230(7):472-8.)
  11. Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status.(Cancer Sci. 2010 Feb;101(2):501-7.)
  12. Soy and its isoflavones: the truth behind the science in breast cancer.(Anticancer Agents Med Chem. 2013 Oct;13(8):1178-87.)
  13. Decreased ovarian hormones during a soya diet: implications for breast cancer prevention.(Cancer Res. 2000 Aug 1;60(15):4112-21.)
  14. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women.(Am J Clin Nutr September 1994 vol. 60 no. 3 333-340)
  15. Childhood soy intake and breast cancer risk in Asian American women.(Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1050-9.)
  16. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans.(Carcinogenesis. 2002 Sep;23(9):1491-6.)
  17. A 2-year soy intervention in premenopausal women does not change mammographic densities.(J Nutr. 2004 Nov;134(11):3089-94.)
  18. Various doses of soy isoflavones do not modify mammographic density in postmenopausal women.(J Nutr. 2009 May;139(5):981-6.)
  19. Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women.(Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2632-8.)
  20. Side effects of phytoestrogens: a meta-analysis of randomized trials.(Am J Med. 2009 Oct;122(10):939-46.e9.)
  21. Intake of Specific Nonfermented Soy Foods May Be Inversely Associated with Risk of Distal Gastric Cancer in a Chinese Population(J Nutr. 2013 Nov; 143(11): 1736–1742.)

  22. Intake of soy products and other foods and gastric cancer risk: a prospective study.(J Epidemiol. 2013 Sep 5;23(5):337-43. Epub 2013 Jun 29.)
  23. Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis.(Eur J Nutr. 2016 Feb;55(1):63-73.)
  24. Soy food consumption and risk of prostate cancer: a meta-analysis of observational studies.(Nutr Cancer. 2009;61(5):598-606.)
  25. Soy and soy isoflavones in prostate cancer: a systematic review and meta-analysis of randomized controlled trials.(BJU Int. 2014 May;113(5b):E119-30.)
  26. Isoflavones and Prostate Cancer: A Review of Some Critical Issues.(Chin Med J (Engl). 2016 5th Feb;129(3):341-347.)
  27. Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function.(Food Funct. 2013 Feb;4(2):200-12.)
  28. Soy, phytoestrogens and metabolism: A review.(Mol Cell Endocrinol. 2009 May 25;304(1-2):30-42.)
  29. The hypoglycemic effects of soy isoflavones on postmenopausal women.(J Womens Health (Larchmt). 2004 Dec;13(10):1080-6.)
  30. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes.(Diabetes Care. 2002 Oct;25(10):1709-14.)
  31. Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial.(Diabetes Care. 2012 Feb;35(2):226-32.)
  32. Effects of Isoflavone Dietary Supplementation on Cardiovascular Risk Factors in Type 2 Diabetes(Published online before printApril 27, 2007, doi:10.2337/dc06-1814)

  33. Effects of soy intake on glycemic control: a meta-analysis of randomized controlled trials.(Am J Clin Nutr. 2011 May;93(5):1092-101.)
  34. Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data.(Curr Opin Clin Nutr Metab Care. 2004 Nov;7(6):649-58.)
  35. Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling.(J Med Food. 2016 Jan;19(1):1-14.)
  36. Phytoestrogens and cognitive function: a review.(Maturitas. 2014 Mar;77(3):209-20.)
  37. Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials.(Menopause. 2012 Jul;19(7):776-90.)
  38. Isoflavone supplements containing predominantly genistein reduce hot flash symptoms: a critical review of published studies.(Menopause. 2006 Sep-Oct;13(5):831-9.)
  39. Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat.(Maturitas. 1995 Apr;21(3):189-95.)
  40. Soy foods, isoflavones, and the health of postmenopausal women.(Am J Clin Nutr. 2014 Jul;100 Suppl 1:423S-30S. )
  41. Effect of soy isoflavone supplementation on menopausal quality of life.(Menopause. 2013 Apr;20(4):443-7.)
  42. Oral intake of soy isoflavone aglycone improves the aged skin of adult women.(J Nutr Sci Vitaminol (Tokyo). 2007 Feb;53(1):57-62.)
  43. Soy isoflavone supplementation could reduce body weight and improve glucose metabolism in non-Asian postmenopausal women—A meta-analysis(January 2013Volume 29, Issue 1, Pages 8–14)

  44. Oxalate and phytate of soy foods.(J Agric Food Chem. 2005 Jul 13;53(14):5670-4.)
  45. Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones(EFSA Journal 2015;13(10):4246 [342 pp.].)

  46. Soy as an endocrine disruptor: cause for caution?(J Pediatr Endocrinol Metab. 2010 Sep;23(9):855-61.)
  47. Reproductive effects in male and female rats of neonatal exposure to genistein.(Reprod Toxicol. 2001 Jul-Aug;15(4):399-411.)
  48. Acute exposure of adult male rats to dietary phytoestrogens reduces fecundity and alters epididymal steroid hormone receptor expression.(J Endocrinol. 2006 Jun;189(3):565-73.)

世界中で注目を集めている日本人の心『緑茶』を見直そう!

  1. In vivo antioxidant effect of green and black tea in man.(European Journal of Clinical Nutrition )
  2. Fluoride content in tea and its relationship with tea quality.(J Agric Food Chem. 2004 Jul 14;52(14):4472-6.)
  3. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects.(Brain Res Brain Res Rev. 1992 May-Aug;17(2):139-70.)
  4. Adenosine, Adenosine Receptors and the Actions of Caffeine(Pharmacology & Toxicology Volume 76,  Issue 2pages 93–101February 1995)
  5. The impact of caffeine on mood, cognitive function, performance and hydration: a review of benefits and risks(Nutrition Bulletin Volume 33,  Issue 1pages 15–25March 2008)
  6. L-theanine—a unique amino acid of green tea and its relaxation effect in humans(Trends in Food Science & Technology Volume 10, Issues 6–7, June 1999, Pages 199–204)

  7. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent.(J Herb Pharmacother. 2006;6(2):21-30.)
  8. L-theanine, a natural constituent in tea, and its effect on mental state.(Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8.)
  9. Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice(Journal of Pharmacological Sciences Vol. 105 (2007) No. 2 P 211-214)

  10. L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance(J. Nutr. August 2008 vol. 138 no. 8 1572S-1577S)
  11. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea()

  12. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men.(Br J Nutr. 2005 Sep;94(3):432-6.)
  13. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans.(Am J Clin Nutr. 1999 Dec;70(6):1040-5.)
  14. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans.(Am J Clin Nutr. 2008 Mar;87(3):778-84.)
  15. Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions.(Br J Nutr. 2009 Oct;102(8):1187-94.)
  16. Caffeine and sports activity: a review.(Int J Sports Med. 1994 Jul;15(5):215-23.)
  17. Effects of caffeine ingestion on metabolism and exercise performance.(Medicine and Science in Sports )
  18. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis(Scandinavian Journal of Medicine & Science in Sports Volume 15,  Issue 2pages 69–78April 2005)
  19. Effects of caffeine ingestion on exercise testing: a meta-analysis.(Int J Sport Nutr Exerc Metab. 2004 Dec;14(6):626-46.)
  20. Oxidative Damage and Cancer(Am J Pathol. 2002 Feb; 160(2): 403–408.)

  21. Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies.(Carcinogenesis. 2006 Jul;27(7):1310-5. Epub 2005 Nov 25.)
  22. Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study(Am. J. Epidemiol. (2008) 167 (1):71-77.)

  23. Prospective cohort study of green tea consumption and colorectal cancer risk in women.(Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1219-23.)
  24. Green tea: cancer preventive beverage and/or drug(Cancer Letters Volume 188, Issues 1–2, 15 December 2002, Pages 9–13)

  25. Cancer-Preventive Effects of Drinking Green Tea among a Japanese Population(Preventive Medicine Volume 26, Issue 6, November 1997, Pages 769–775)

  26. Cancer inhibition by green tea(Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Volume 402, Issues 1–2, 18 June 1998, Pages 307–310)

  27. Addition of whole, semiskimmed, and skimmed bovine milk reduces the total antioxidant capacity of black tea.(Nutr Res. 2010 Jan;30(1):14-20.)
  28. Neurological mechanisms of green tea polyphenols in Alzheimer’s and Parkinson’s diseases.(J Nutr Biochem. 2004 Sep;15(9):506-16.)
  29. Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.(CNS Neurosci Ther. 2008 Winter;14(4):352-65.)
  30. Potential Therapeutic Properties of Green Tea Polyphenols in Parkinson’s Disease(Drugs & Aging Volume 20, Issue 10, pp 711-721)

  31. The bactericidal activity of tea and coffee(Letters in Applied Microbiology Volume 8,  Issue 4pages 123–125April 1989)
  32. Antimicrobial effects of green tea polyphenols on thermophilic spore-forming bacteria(Journal of Bioscience and Bioengineering Volume 90, Issue 1, 2000, Pages 81–85)

  33. Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens.(Poult Sci. 2012 Jan;91(1):66-73.)
  34. Antiviral effect of catechins in green tea on influenza virus.(Antiviral Res. 2005 Nov;68(2):66-74.)
  35. Anticaries Effects of Polyphenolic Compounds from Japanese Green Tea(Caries Res 1991;25:438–443)

  36. Combination effects of antibacterial compounds in green tea flavor against Streptococcus mutans(J. Agric. Food Chem.199341 (7), pp 1102–1105)

  37. Antibacterial Activity of Iranian Green and Black Tea on Streptococcus MutansAn In Vitro Study(J Dent (Tehran). 2011 Spring; 8(2): 55–59.)

  38. Green tea: a promising natural product in oral health.(Arch Oral Biol. 2012 May;57(5):429-35.)
  39. Anticariogenic effects of green tea.(Fukuoka Igaku Zasshi. 1992 Apr;83(4):174-80.)
  40. Not Found
  41. Effect of green tea on volatile sulfur compounds in mouth air.(J Nutr Sci Vitaminol (Tokyo). 2008 Feb;54(1):89-94.)
  42. Effect of tea catechins for halitosis and their application to chewing gum(Effect of tea catechins for halitosis and their application to chewing gum)

  43. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials.(Am J Clin Nutr. 2013 Aug;98(2):340-8.)
  44. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults.(Ann Intern Med. 2006 Apr 18;144(8):554-62.)
  45. Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type 2 Diabetes MellitusA Systematic Review With Meta-analysis(Arch Intern Med. 2009;169(22):2053-2063.)

  46. The top 10 causes of death(WHO web site)

  47. Antihypercholesterolemic effect of Chinese black tea extract in human subjects with borderline hypercholesterolemia.(Nutr Res. 2008 Jul;28(7):450-6.)
  48. Inhibitory effect of Chinese green tea on endothelial cell-induced LDL oxidation(Atherosclerosis Volume 148, Issue 1, January 2000, Pages 67–73)

  49. Inhibitory effect of jasmine green tea epicatechin isomers on LDL-oxidation(The Journal of Nutritional Biochemistry Volume 8, Issue 6, June 1997, Pages 334–340)

  50. Influence of green tea and its three major components upon low-density lipoprotein oxidation(Experimental and Toxicologic Pathology Volume 49, Issue 5, December 1997, Pages 329–335)

  51. The Relation between Green Tea Consumption and Cardiovascular Disease as Evidenced by Epidemiological Studies(J. Nutr. August 2008 vol. 138 no. 8 1548S-1553S)
  52. Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study(Int. J. Epidemiol. (2007) 36 (3):600-609.)

  53. Does Tea Affect Cardiovascular Disease? A Meta-Analysis(Am. J. Epidemiol. (2001) 154 (6):495-503.)

  54. Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial(Physiology & Behavior Volume 93, Issue 3, 27 February 2008, Pages 486–491)

  55. Effects of catechin enriched green tea on body composition.(Obesity (Silver Spring). 2010 Apr;18(4):773-9.)
  56. A Green Tea Extract High in Catechins Reduces Body Fat and Cardiovascular Risks in Humans(Obesity Volume 15,  Issue 6pages 1473–1483June 2007)
  57. Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors.(J Hum Nutr Diet. 2010 Dec;23(6):590-600.)
  58. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study.(JAMA. 2006 Sep 13;296(10):1255-65.)
  59. Green Tea Consumption and Mortality among Japanese Elderly People: The Prospective Shizuoka Elderly Cohort(Annals of Epidemiology Volume 19, Issue 10, October 2009, Pages 732–739)

『フルーツジュース』が実は健康に悪い理由を5個言います!

  1. Fruit juice: just another sugary drink?(The Lancet Volume 2, No. 6, p444–446, June 2014)

  2. SELF NutritionData web site
  3. Bioavailability and antioxidant effects of orange juice components in humans.(J Agric Food Chem. 2005 Jun 29;53(13):5170-8.)
  4. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression(Am J Clin Nutr. 2010 Apr; 91(4): 940–949.)

  5. Deconstructing a fruit serving: comparing the antioxidant density of select whole fruit and 100% fruit juices.(J Acad Nutr Diet. 2013 Oct;113(10):1354-8.)
  6. A satiety index of common foods.(Eur J Clin Nutr. 1995 Sep;49(9):675-90.)
  7. How bad is fructose?(Current Issue February 2016, 103 (2))
  8. Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men(Diabetes July 2005 vol. 54 no. 7 1907-1913)

  9. Fructose consumption as a risk factor for non-alcoholic fatty liver disease(Journal of Hematology June 2008Volume 48, Issue 6, Pages 993–999)

  10. Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): A population based study(Journal of Hematology Volume 47, Issue 5, November 2007, Pages 711–717)

  11. Fructose, insulin resistance, and metabolic dyslipidemia(Nutrition & Metabolism20052:5)

  12. Fructose, weight gain, and the insulin resistance syndrome(Am J Clin Nutr November 2002 vol. 76 no. 5 911-922)
  13. Endocrine and metabolic effects of consuming beverages sweetened with fructose, glucose, sucrose, or high-fructose corn syrup(Am J Clin Nutr December 2008 vol. 88 no. 6 1733S-1737S)

  14. Metabolic effects of fructose and the worldwide increase in obesity.(Physiol Rev. 2010 Jan;90(1):23-46.)
  15. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans(J Clin Invest. 2009 May 1; 119(5): 1322–1334.)

  16. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults.(J Am Coll Nutr. 2009 Oct;28(5):574-82.)
  17. Fructose-Rich Beverages and the Risk of Gout in Women(JAMA. 2010 Nov 24; 304(20): 2270–2278.)

  18. “A calorie is a calorie” violates the second law of thermodynamics(Nutrition Journal20043:9)

  19. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and gherkin concentrations(Am J Clin Nutr July 2005 vol. 82 no. 1 41-48)
  20. Caloric compensation and eating in the absence of hunger in 5- to 12-y-old weight-discordant siblings(Am J Clin Nutr September 2012 
    vol. 96 no. 3 574-583)

  21. Effects of food form and timing of ingestion on appetite and energy intake in lean young adults and in young adults with obesity.(J Am Diet Assoc. 2009 Mar;109(3):430-7.)
  22. Intake of sugar-sweetened beverages and weight gain: a systematic review(Am J Clin Nutr August 2006 vol. 84 no. 2 274-288)
  23. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis(THE LANCET Volume 357, Issue 9255, 17 February 2001, Pages 505–508)

  24. Fruit Juice Intake Predicts Increased Adiposity Gain in Children From Low-Income Families: Weight Status-by-Environment Interaction(Pediatrics November 2006, VOLUME 118 / ISSUE 5)

  25. Reducing childhood obesity by eliminating 100% fruit juice.(Am J Public Health. 2012 Sep;102(9):1630-3.)
  26. Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies(BMJ 2013347)

  27. Intake of Fruit, Vegetables, and Fruit Juices and Risk of Diabetes in Women(Diabetes Care. 2008 Jul; 31(7): 1311–1317.)

  28. Soft drink and juice consumption and risk of physician-diagnosed incident type 2 diabetes: the Singapore Chinese Health Study.(Am J Epidemiol. 2010 Mar 15;171(6):701-8.)

炭酸飲料やジュースが体に悪い『13個の理由』を徹底解説!

  1. Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women(JCEM 2003, vol89; issue6)
  2. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways.(JAMA. 2013 Jan 2;309(1):63-70.)
  3. Effects of Soft Drink Consumption on Nutrition and Health: A Systematic Review and Meta-Analysis(Am J Public Health. 2007 April; 97(4): 667–675.)

  4. Effects of Soft Drink Consumption on Nutrition and Health: A Systematic Review and Meta-Analysis(Am J Public Health. 2007 April; 97(4): 667–675.)

  5. Effects of carbohydrates on satiety: differences between liquid and solid food.(Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):385-90.)
  6. Liquid versus solid carbohydrate: effects on food intake and body weight.(Int J Obes Relat Metab Disord. 2000 Jun;24(6):794-800.)
  7. Intake of sugar-sweetened beverages and weight gain: a systematic review(Am J Clin Nutr August 2006 vol. 84 no. 2 274-288)
  8. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity(Am J Clin Nutr April 2004 vol. 79 no. 4 537-543)
  9. Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial(Errata – May 20, 2004)

  10. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis.(Lancet. 2001 Feb 17;357(9255):505-8.)
  11. How bad is fructose?(Am J Clin Nutr October 2007 vol. 86 no. 4 895-896)
  12. Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men(Diabetes July 2005 vol. 54 no. 7 1907-1913)

  13. Fructose consumption as a risk factor for non-alcoholic fatty liver disease(J. Hepatology June 2008Volume 48, Issue 6, Pages 993–999)

  14. Fructose-Induced Fatty Liver Disease Hepatic Effects of Blood Pressure and Plasma Triglyceride Reduction(Hypertension.2005; 45: 1012-1018)

  15. Greater Fructose Consumption Is Associated with Cardiometabolic Risk Markers and Visceral Adiposity in Adolescents(J Nutr. 2012 Feb; 142(2): 251–257.)

  16. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans(J Clin Invest. 2009 May 1; 119(5): 1322–1334.)

  17. Fructose, insulin resistance, and metabolic dyslipidemia(Nutrition & Metabolism20052:5)

  18. Fructose, weight gain, and the insulin resistance syndrome(Am J Clin Nutr November 2002 vol. 76 no. 5 911-922)
  19. Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats.(Am J Clin Nutr June 1989 vol. 49 no. 6 1155-1163)
  20. Fructose induced lipogenesis: from sugar to fat to insulin resistance(Endocrinology & Metabolism Volume 22, Issue 2, February 2011, Pages 60–65)

  21. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis.(Diabetes Care. 2010 Nov;33(11):2477-83.)
  22. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women.(JAMA. 2004 Aug 25;292(8):927-34.)
  23. Sugar-sweetened and artificially sweetened beverage consumption and risk of type 2 diabetes in men.(Am J Clin Nutr. 2011 Jun;93(6):1321-7.)
  24. Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct.(Diabetologia. 2013 Jul;56(7):1520-30.)
  25. The Relationship of Sugar to Population-Level Diabetes Prevalence: An Econometric Analysis of Repeated Cross-Sectional Data

  26. Leptin: a review of its peripheral actions and interactions.(Int J Obes Relat Metab Disord. 2002 Nov;26(11):1407-33.)
  27. 20 YEARS OF LEPTIN: Connecting leptin signaling to biological function(J Endocrinol October 1, 2014 223 T25-T35)

  28. Leptin and the regulation of body weight in mammals(Nature395, 763-770 (22 October 1998))

  29. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism(MetabolismVolume 64, Issue 1, January 2015, Pages 24–34)

  30. Molecular mechanisms of central leptin resistance in obesity.(Arch Pharm Res. 2013 Feb;36(2):201-7.)
  31. Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.(Br J Nutr. 2011 Aug;106(3):390-7.)
  32. Dietary components in the development of leptin resistance.(Adv Nutr. 2013 Mar 1;4(2):164-75.)
  33. Daily bingeing on sugar repeatedly releases dopamine in the accumbent shell(NeuroscienceVolume 134, Issue 3, 2005, Pages 737–744)

  34. Neurobiology of food addiction.(Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):359-65.)
  35. Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake(Neurosci Biobehav Rev. 2008; 32(1): 20–39.)

  36. Sweet preference, sugar addiction and the familial history of alcohol dependence: shared neural pathways and genes.(J Psychoactive Drugs. 2010 Jun;42(2):147-51.)
  37. Animal models of sugar and fat bingeing: relationship to food addiction and increased body weight.(Methods Mol Biol. 2012;829:351-65.)
  38. Sugar and ischaemic heart disease.(Practitioner. 1967 May;198(187):680-3.)
  39. Dietary factors in arteriosclerosis: sucrose.(Lipids. 1978 May;13(5):370-2.)
  40. Consumption of Added Sugars and Indicators of Cardiovascular Disease Risk Among US Adolescents(Circulation.2011; 123: 249-257)

  41. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women(Am J Clin Nutr June 2000 vol. 71 no. 6 1455-1461)
  42. Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men.(Circulation.2012Apr10;125(14):1735-41)
  43. Sweetened beverage consumption and risk of coronary heart disease in women.(Am J Clin Nutr. 2009 Apr;89(4):1037-42.)
  44. SUGAR-SWEETENED BEVERAGE, SUGAR INTAKE OF INDIVIDUALS AND THEIR BLOOD PRESSURE: INTERMAP STUDY(Hypertension. 2011 Apr; 57(4): 695–701.)

  45. Reducing Consumption of Sugar-Sweetened Beverages Is Associated with Reduced Blood Pressure: A Prospective Study among U.S. Adults(Circulation. 2010 Jun 8; 121(22): 2398–2406.)

  46. Association of sweetened beverage intake with incident hypertension.(J Gen Intern Med. 2012 Sep;27(9):1127-34.)
  47. Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men.(Circulation. 2012 Apr 10;125(14):1735-41,)
  48. Soft Drink and Juice Consumption and Risk of Pancreatic Cancer: The Singapore Chinese Health Study(Cancer Epidemiol Biomarkers Prev. 2010 Feb; 19(2): 447–455.)

  49. Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts.(Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2098-105.)
  50. Sugar-Sweetened Beverage Intake and the Risk of Type I and Type II Endometrial Cancer among Postmenopausal Women(Cancer Epidemiol Biomarkers PrevDecember 2013 22; 2384)

  51. Sugar-Sweetened Beverage Intake and Cancer Recurrence and Survival in CALGB 89803 (Alliance)

  52. Comparison of the Cariogenicity of Cola, Honey, Cow Milk, Human Milk, and Sucrose(PediatricsOctober 2005, VOLUME 116 / ISSUE 4)

  53. Cariogenicity of soft drinks, milk and fruit juice in low-income african-american children: a longitudinal study.(J Am Dent Assoc. 2008 Jul;139(7):959-67)
  54. Sugars and dental caries(Am J Clin Nutr October 2003 
    vol. 78 no. 4 881S-892S)
  55. Dental erosion and severe tooth decay related to soft drinks: a case report and literature review(J Zhejiang Univ Sci B. 2009 May; 10(5): 395–399.)

  56. Gout: An Evidence-Based Review(JCR: Journal of Clinical Rheumatology:October 2008 – Volume 14 – Issue 5S – pp S55-S62)
  57. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study(BMJ 2008;336:309)

  58. Fructose-rich beverages and risk of gout in women.(JAMA. 2010 Nov 24;304(20):2270-8.)
  59. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study(BMJ 2008;336:309)

  60. Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study.(BMJ. 2008 Feb 9;336(7639):309-12.)
  61. High-sugar diets, type 2 diabetes and Alzheimer’s disease.(Curr Opin Clin Nutr Metab Care. 2013 Jul;16(4):440-5)
  62. Glucose Levels and Risk of Dementia(N Engl J Med 2013; 369:540-548)
  63. Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats(Hippocampus Volume 25,  Issue 2pages 227–239February 2015)

『フッ素』が脳みそに悪影響を与えるだとぅっ!!

  1. Alteration of mitochondrial distribution and gene expression of fission 1 protein in cortical neurons of rats with chronic fluorosis(Zhonghua Bing Li Xue Za Zhi 41(4):243-7.)
  2. Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels.(Neurotoxicity Research 2011, 9(1):55-62.)
  3. Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: a multigenerational assessment.(Biological Trace Element Research December 2011 144(1-3):1083-94.)
  4. Effects of fluoride on synaptic membrane fluidity and PSD-95 expression level in rat hippocampus.(Biol Trace Elem Res.  February 2011139(2):197-203.)
  5. Increased level of apoptosis in rat brains and SH-SY5Y cells exposed to excessive fluoride–a mechanism connected with activating JNK phosphorylation. (Toxicol Lett. 204(2-3):183-9.)
  6. Proteomic analysis of brain proteins of rats exposed to high fluoride and low iodine. (Arch. Toxicol. 85:27-33.)
  7. Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats. (J Appl Toxicol. 30(1):63-73.)
  8. Changes of learning and memory ability and brain nicotinic receptors of rat offspring with coal burning fluorosis. (Neurotoxicol Teratol. 32(5):536-41.)
  9. Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory. (Toxicol Lett. 192(3):324-9.)
  10. Effect of concurrent chronic exposure of fluoride and aluminum on rat brain. (Drug & Chem. Toxicol. 32(3): 215-21.)
  11. Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead. (Environ Toxicol Pharmacol. 28(2):254-8.)
  12. Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain.( J Neurol Sci. 285(1-2):198-205.)
  13. Protective effects of selenium on fluoride induced alterations in certain enzymes in brain of mice. (J Environ Biol. 30(5 Suppl):859-64.)
  14.  Biochemical changes in brain and other tissues of young adult female mice from fluoride in their drinking water. (Fluoride 39(4):280-84.)
  15. Comet assay of DNA damage in brain cells of adult rats exposed to high fluoride and low iodine. (Fluoride 38:209-14.)
  16. Biochemical effects of sodium fluoride and arsenic trioxide toxicity and their reversal in the brain of mice. (Fluoride 37: 80-87.)
  17. Adverse effects of fluoride and/or arsenic on the cerebral hemisphere of mice and recovery by some antidotes.(Fluoride 37(3): 162-171.)
  18. Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. (Fluoride 37: 201-208.)
  19. Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. (Fluoride 37(4):264–270.)
  20. Decreased nicotinic receptors in PC12 cells and rat brains influenced by fluoride toxicity—a mechanism relating to a damage at the level in post-transcription of the receptor genes. (Toxicology 200: 169–177.)
  21. Influence of combined iodine and fluoride on phospholipid and fatty acid composition in brain cells of rats(Wei Sheng Yan Jiu. 33:158-61.)
  22. Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to fluoride.(Toxicology 183: 235-42.)
  23. Histopathological investigation of fluoride-induced neurotoxicity in rabbits. (Fluoride 36: 95-105.)
  24. Studies on fluoride concentration and cholinesterase activity in rat hippocampus( Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21:102-4.)
  25. Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice.(Indian Journal of Experimental Biology 40: 546-54.)
  26. Studies on DNA damage and apoptosis in rat brain induced by fluoride(Zhonghua Yu Fang Yi Xue Za Zhi 36: 222-224.)
  27. Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain.(Neurotoxicology and Teratology 24:751-7.)
  28. Brain lipid peroxidation and antioxidant systems of young rats in chronic fluoride intoxication. (Fluoride 35: 197-203.)
  29. Histological changes in the brain of young fluoride-intoxicated rats.(Fluoride 35: 12-21.)
  30. Effects of selenium and zinc on the DNA damage caused by fluoride in pallium neural cells of rats(Wei Sheng Yan Jiu. 29: 216-7.)
  31. Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice. (Fluoride 33: 17-26.)
  32. Study of the mechanism of neurone apoptosis in rats from the chronic fluorosis. (Chinese Journal of Epidemiology 19: 96-98.)
  33. Influence of free radical inducer on the level of oxidative stress in brain of rats with fluorosis]. (Zhonghua Yu Fang Yi Xue Za Zhi 34:330-2.)
  34. Fluoride enhances the effect of aluminium chloride on interconnections between aggregates of hippocampal neurons. (Archives of Physiology and Biochemistry 107:15-21.)

  35. Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice](Wei Sheng Yan Jiu 28:210-2.)
  36. Influence of chronic fluorosis on membrane lipids in rat brain. (Neurotoxicology and Teratology 20: 537-542.)
  37. Chronic administration of aluminum-fluoride and sodium-fluoride to rats in drinking water: Alterations in neuronal and cerebrovascular integrity. (Brain Research 784: 284-298.)
  38. Actions of sodium fluoride on acetylcholinesterase activities in rats. (Biomedical and Environmental Sciences 11(1):1-6.)
  39. Influence of experimental fluorosis on phospholipid content and fatty acid composition in rat brain(Zhonghua Yi Xue Za Zhi. 77: 592-6.)
  40. Toxin-induced blood vessel inclusions caused by the chronic administration of aluminum and sodium fluoride and their implications for dementia.(Annals of the New York Academy of Science 825: 152-166.)
  41. Changes of coenzyme Q content in brain tissues of rats with fluorosis].(Zhonghua Yu Fang Yi Xue Za Zhi. 31: 330-3.)
  42. Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism](Hua Hsi I Ko Ta Hsueh Hsueh Pao. 25(2):188-91.)
  43. Effect of long-term administration of fluoride on levels of protein, free amino acids and RNA in rabbit brain. (Fluoride 27: 155-159.)
  44. Studies on alterations in brain lipid metabolism following experimental fluorosis. (Fluoride 25:77-84.)
  45. Inferring the fluoride hydrogeochemistry and effect of consuming fluoride-contaminated drinking water on human health in some endemic areas of Birbhum district, West Bengal.(Environmental Geochemistry & Health)
  46. A cross-sectional study to assess the intelligence quotient (IQ) of school going children aged 10-12 years in villages of Mysore district, India with different fluoride levels.(Journal of the Indian Society of Pedodontics and Preventive Dentistry 33(4):307-11.)
  47. Effect of fluoride in drinking water on children’s intelligence in high and low fluoride areas of Delhi. (Journal of the Indian Association of Public Health Dentistry13(2):116-121. April-June.)
  48. Association of lifetime exposure to fluoride and cognitive functions in Chinese children: A pilot study.(Neurotoxicology & Teratology 47:96-101.)

歯の守護者・スーパーヒーロー『フルオライド』!!

  1. 5 Reasons Why Fluoride in Water is Good for Communities(ADA web site)
  2. The Superhero That Lives Inside Your Mouth(ADA web site)

知られざる『ビタミンK』の秘密ワールドへようこそ!

  1. Vitamin K Metabolism(Fat-Soluble Vitamins Volume 30 of the series Subcellular Biochemistry pp 455-488)

  2. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.(Blood. 2007 Apr 15;109(8):3279-83. Epub 2006 Dec 7.)
  3. Intracellular Calcium Homeostasis and Signaling(Metallomics and the Cell Volume 12 of the series Metal Ions in Life Sciences pp 119-168)

  4. Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats.(J Vasc Res. 2003 Nov-Dec;40(6):531-7.)
  5. Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis.(BMJ. 2013 Mar 25;346:f1654)
  6. Coronary calcium as a predictor of coronary events in four racial or ethnic groups.(N Engl J Med. 2008 Mar 27;358(13):1336-45.)
  7. Coronary calcification score: the coronary-risk impact factor.(Lancet. 2004 Feb 14;363(9408):557-9.)
  8. Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review(Oman Med J. 2014 May; 29(3): 172–177.)

  9. Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study(J. Nutr. November 1, 2004 vol. 134 no. 11 3100-3105)
  10. A high menaquinone intake reduces the incidence of coronary heart disease.(Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):504-10.)
  11. Vitamin K Status and Vascular Calcification: Evidence from Observationaland Clinical Studies1,2(American Society for Nutrition. Adv. Nutr. 3: 158–165, 2012)
  12. The top 10 causes of death(WHO web site)
  13. Vitamin K Nutrition, Metabolism, and Requirements: Current Concepts and Future Research(Adv Nutr March 2012 Adv Nutr vol. 3: 182-195, 2012)

  14. Vitamin K Deficiency Is Associated with Incident Knee Osteoarthritis(The American Journal of Medicine March 2013Volume 126, Issue 3, Pages 243–248)

  15. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women(Osteoporosis International Volume 24, Issue 9, pp 2499-2507)

  16. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.(Arch Intern Med. 2006 Jun 26;166(12):1256-61.)
  17. Vitamin K2(Clin Calcium. 2008 Oct;18(10):1476-82.)
  18. Vitamin K and musculoskeletal health in postmenopausal women(Molecular Nutrition & Food Research Special Issue: Vitamin K Conundrums Volume 58,  Issue 8pages 1647–1657August 2014)
  19. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials(Journal of Bone and Mineral Metabolism Volume 30, Issue 1, pp 60-68)

  20. Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro.(J Bone Miner Res. 1997 Mar;12(3):431-8.)
  21. Induction of type I collagen and osteocalcin in human dental pulp cells by retinoic acid.(Southeast Asian J Trop Med Public Health. 2005 Jul;36(4):1066-9.)
  22. Formation of odontoblast-like cells from cultured human dental pulp cells on dentin in vitro.(J Endod. 2006 Nov;32(11):1066-73.)
  23. Effect of retinoic acid on osteocalcin gene expression in human osteoblasts.(Biochem Biophys Res Commun. 1993 Mar 31;191(3):908-14.)
  24. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study.(Cancer. 2006 Feb 15;106(4):867-72.)
  25. Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial.(Anticancer Res. 2012 Dec;32(12):5415-20.)
  26. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg).(Am J Clin Nutr. 2008 Apr;87(4):985-92.)
  27. The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis.(Prog Food Nutr Sci. 1992 Oct-Dec;16(4):307-43.)
  28. Reduction of vitamin K2 concentrations in human liver associated with the use of broad spectrum antimicrobials.(Clin Invest Med. 1994 Dec;17(6):531-9.)
  29. Nutritional Intake of Vitamins K1 (Phylloquinone) and K2 (Menaquinone) in The Netherlands(Journal of Nutritional & Environmental Medicine Volume 9, Issue 2, 1999)
  30. Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations.(Haemostasis. 2000 Nov-Dec;30(6):298-307.)
  31. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.(Altern Med Rev. 2010 Sep;15(3):199-222.)
  32. Calories in Japanese foods(http://www.eiyoukeisan.com)

砂糖の様で砂糖じゃない!『エリスリトール』の不思議!

  1. Serum glucose and insulin levels and erythritol balance after oral administration of erythritol in healthy subjects.(Eur J Clin Nutr. 1994 Apr;48(4):286-92.)
  2. Similarity of the effects of erythritol and xylitol on some risk factors of dental caries.(Caries Res. 2005 May-Jun;39(3):207-15.)
  3. Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci.(Caries Res. 2001 Mar-Apr;35(2):129-35.)
  4. The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized clinical trial in an area of natural fluoridation.(Int J Paediatr Dent. 2012 May;22(3):180-90.)
  5. Effect of erythritol and xylitol on dental caries prevention in children.(Caries Res. 2014;48(5):482-90.)
  6. Human gut microbiota does not ferment erythritol(British Journal of Nutrition / Volume 94 / Issue 05 / November 2005, pp 643-646)
  7. Metabolism of erythritol in humans: Comparison with glucose and lactitol(British Journal of Nutrition / Volume 69 / Issue 01 / January 1993, pp 169-176)
  8. Tolerance to Subchronic, High-Dose Ingestion of Erythritol in Human Volunteers(Regulatory Toxicology and PharmacologyVolume 24, Issue 2, October 1996, Pages S286–S295)

  9. Laxative threshold of sugar alcohol erythritol in human subjects(Nutrition ResearchVolume 16, Issue 4, April 1996, Pages 577–589)

  10. Gastrointestinal tolerance of erythritol and xylitol ingested in a liquid(European Journal of Clinical Nutrition (2007) 61, 349–354.)

  11. Chronic toxicity and carcinogenicity study of erythritol in rats.(Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 2):S264-79.)
  12. Erythritol: an interpretive summary of biochemical, metabolic, toxicological and clinical data.(Food Chem Toxicol. 1998 Dec;36(12):1139-74.)
  13. Fueling the obesity epidemic? Artificially sweetened beverage use and long-term weight gain.(Obesity (Silver Spring). 2008 Aug;16(8):1894-900.)
  14. Artificial sweetener use and one-year weight change among women(Preventive MedicineVolume 15, Issue 2, March 1986, Pages 195-202)

  15. Diet Soda Intake and Risk of Incident Metabolic Syndrome and Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA)(Diabetes Care April 2009 vol. 32 no. 4 688-694)

  16. Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidémiologique auprès des femmes de la Mutuelle Générale de l’Education Nationale–European Prospective Investigation into Cancer and Nutrition cohort(Am J Clin Nutrajcn.050997)

  17. Gain weight by “going diet?” Artificial sweeteners and the neurobiology of sugar cravings(Yale J Biol Med. 2010 Jun; 83(2): 101–108.)

ルールを守って水を飲むだけで得られる『7個』の健康利益!

  1. Hydration and physical performance.(J Am Coll Nutr. 2007 Oct;26(5 Suppl):542S-548S.)
  2. Hydration and Muscular Performance(Sports Medicine Volume 37, Issue 10, pp 907-921)

  3. Water, Hydration and Health(Nutr Rev. 2010 Aug; 68(8): 439–458.)

  4. Fluid replacement following dehydration reduces oxidative stress during recovery.(Biochem Biophys Res Commun. 2009 May 22;383(1):103-7.)
  5. “Drink at least eight glasses of water a day.” Really? Is there scientific evidence for “8 × 8”?()

  6. Mild dehydration affects mood in healthy young women.(J Nutr. 2012 Feb;142(2):382-8.)
  7. Mild dehydration impairs cognitive performance and mood of men.(Br J Nutr. 2011 Nov;106(10):1535-43.)
  8. The Hydration Equation: Update on Water Balance and Cognitive Performance(ACSMs Health Fit J. 2013 November/December; 17(6): 21–28.)

  9. Influence of progressive fluid restriction on mood and physiological markers of dehydration in women.(Br J Nutr. 2013 Jan 28;109(2):313-21.)
  10. Water intake and post-exercise cognitive performance: an observational study of long-distance walkers and runners.(Eur J Nutr. 2013 Mar;52(2):617-24.)
  11. Effects of drinking supplementary water at school on cognitive performance in children.(Appetite. 2012 Dec;59(3):730-7.)
  12. Effects of fluid ingestion on cognitive function after heat stress or exercise-induced dehydration(International Journal of Psychophysiology Volume 42, Issue 3, November 2001, Pages 243–251)
  13. The relation of hydration status to cognitive performance in healthy older adults.(Int J Psychophysiol. 2004 Jul;53(2):121-5.)
  14. Water deprivation: a new migraine precipitant.(Headache. 2005 Jun;45(6):757-9.)
  15. The effects of fluid restriction on hydration status and subjective feelings in man.(Br J Nutr. 2004 Jun;91(6):951-8.)
  16. Water-deprivation headache: a new headache with two variants.(Headache. 2004 Jan;44(1):79-83.)
  17. Increasing the daily water intake for the prophylactic treatment of headache: a pilot trial.(Eur J Neurol. 2005 Sep;12(9):715-8.)
  18. Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women(European Journal of Clinical Nutrition (2007) 61, 616–622.)

  19. Development of constipation in nursing home residents.(Dis Colon Rectum. 2000 Jul;43(7):940-3.)
  20. [Effects of carbonated water intake on constipation in elderly patients following a cerebrovascular accident].(J Korean Acad Nurs. 2011 Apr;41(2):269-75.)
  21. Effects of carbonated water on functional dyspepsia and constipation.(Eur J Gastroenterol Hepatol. 2002 Sep;14(9):991-9.)
  22. The In uence of Increased Fluid Intake in the Prevention of Urinary Stone Formation: a Systematic Review(Acta Med Indones-Indones J Intern Med;253-258)
  23. Water for preventing urinary stones(Cochrane Library)

  24. Hydration status and the diuretic action of a small dose of alcohol.(Alcohol Alcohol. 2010 Jul-Aug;45(4):366-73.)
  25. Effect of ethanol ingestion on plasma vasopressin and water balance in humans.(Am J Physiol. 1982 May;242(5):R522-7.)
  26. Water-induced thermogenesis.(J Clin Endocrinol Metab. 2003 Dec;88(12):6015-9.)
  27. Water Drinking Induces Thermogenesis through Osmosensitive Mechanisms(JCEM: 2006, vol.92, issue8)
  28. Water consumption reduces energy intake at a breakfast meal in obese older adults.(J Am Diet Assoc. 2008 Jul;108(7):1236-9.)
  29. Pre-meal water consumption reduces meal energy intake in older but not younger subjects.(Obesity (Silver Spring). 2007 Jan;15(1):93-9.)
  30. Water consumption increases weight loss during a hypocaloric diet intervention in middle-aged and older adults.(Obesity (Silver Spring). 2010 Feb;18(2):300-7.)
  31. Fluid Intake and the Risk of Bladder Cancer in Men(N Engl J Med 1999; 340:1390-1397)
  32. Nutritional and lifestyle habits and water-fiber interaction in colorectal adenoma etiology.(Cancer Epidemiol Biomarkers Prev. 1997 Feb;6(2):79-85.)
  33. Fluid consumption and the risk of bladder cancer: results of a multicenter case-control study.(Int J Cancer. 2001 Sep;93(6):880-7.)
  34. Relationship of food groups and water intake to colon cancer risk.(Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):495-502.)

人工甘味料『アスパルテーム』は体に悪い??噂を徹底検証!

  1. Treating phenylketonuria by a phenylalanine-free diet.(Prof Care Mother Child. 1998;8(4):109-10.)
  2. Diet in phenylketonuria: how long? Policies under discussion.(Ann Nutr Metab. 1998;42(2):63-7.)
  3. Effect of storage conditions on methanol content of fruit and vegetable juices(Journal of Food Composition and Analysis Volume 21, Issue 5, August 2008, Pages 410–415)

  4. Endogenous production of methanol after the consumption of fruit.(Alcohol Clin Exp Res. 1997 Aug;21(5):939-43.)
  5. Urinary excretion of methanol and 5-hydroxytryptophol as biochemical markers of recent drinking in the hangover state.(Alcohol Alcohol. 1998 Jul-Aug;33(4):431-8.)
  6. Influence of apple cultivar and juice pasteurization on hard cider and eau-de-vie methanol content.(Bioresour Technol. 2010 Feb;101(4):1396-8.)
  7. Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues.(Food Chem Toxicol. 2013 Oct;60:109-15.)
  8. Aspartame sensitivity? A double blind randomised crossover study.(PLoS One. 2015 Mar 18;10(3):e0116212.)
  9. Aspartame: review of safety.(Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 2):S1-93.)
  10. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats.(Environ Health Perspect. 2006 Mar;114(3):379-85.)
  11. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats.(Environ Health Perspect. 2007 Sep;115(9):1293-7.)
  12. Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.(Am J Ind Med. 2010 Dec;53(12):1197-206.)
  13. Carcinogenicity of Aspartame in Rats Not Proven(Environ Health Perspect. 2008 Jun; 116(6): A239–A240.)

  14. Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women.(Am J Clin Nutr. 2012 Dec;96(6):1419-28.)
  15. Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies.(Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1654-9.)
  16. Aspartame consumption in relation to childhood brain tumor risk: results from a case-control study.(J Natl Cancer Inst. 1997 Jul 16;89(14):1072-4.)
  17. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies.(Crit Rev Toxicol. 2007;37(8):629-727.)
  18. Artificial sweeteners–do they bear a carcinogenic risk?(Ann Oncol. 2004 Oct;15(10):1460-5.)
  19. A review of the effectiveness of aspartame in helping with weight control(Nutrition Bulletin Volume 31,  Issue 2pages 115–128June 2006)
  20. The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight.(Am J Clin Nutr. 1997 Feb;65(2):409-18.)
  21. Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight.(Am J Clin Nutr. 1990 Jun;51(6):963-9.)
  22. Direct and indirect cellular effects of aspartame on the brain.(Eur J Clin Nutr. 2008 Apr;62(4):451-62.)
  23. Aspartame effects on the brain.(Eur J Clin Nutr. 2009 May;63(5):698-9)
  24. Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects.(Am J Clin Nutr. 1998 Sep;68(3):531-7.)
  25. The neuropsychiatric effects of aspartame in normal volunteers.(J Clin Pharmacol. 1990 May;30(5):454-60.)
  26. Phenylalanine and aspartame fail to alter feeding behavior, mood and arousal in men.(Physiol Behav. 1987;39(2):247-53.)
  27. Aspartame- or sugar-sweetened beverages: effects on mood in young women.(J Am Diet Assoc. 1990 Feb;90(2):250-4.)
  28. Effects of alcohol and chronic aspartame ingestion upon performance in aviation relevant cognitive tasks.(Aviat Space Environ Med. 1994 Jan;65(1):7-15.)
  29. Effects of sugar and aspartame on aggression and activity in children.(Am J Psychiatry. 1987 Nov;144(11):1487-90.)
  30. Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children.(N Engl J Med. 1994 Feb 3;330(5):301-7.)
  31. Aspartame, behavior, and cognitive function in children with attention deficit disorder.(Pediatrics. 1994 Jan;93(1):70-5.)
  32. Sugar consumption, locomotion, task orientation, and learning in preschool children.(J Abnorm Child Psychol. 1989 Jun;17(3):349-57.)
  33. Aspartame: effects on learning, behavior, and mood.(Pediatrics. 1990 Jul;86(1):75-83.)
  34. Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.(Biol Psychiatry. 1993 Jul 1-15;34(1-2):13-7.)
  35. Aspartame has no effect on seizures or epileptiform discharges in epileptic children.(Ann Neurol. 1994 Jan;35(1):98-103.)
  36. Aspartame and seizure susceptibility: results of a clinical study in reportedly sensitive individuals.(Epilepsia. 1995 Mar;36(3):270-5.)
  37. Aspartame exacerbates EEG spike-wave discharge in children with generalized absence epilepsy: a double-blind controlled study.(Neurology. 1992 May;42(5):1000-3.)
  38. Aspartame and susceptibility to headache.(N Engl J Med. 1987 Nov 5;317(19):1181-5.)
  39. The effect of aspartame on migraine headache.(Headache. 1988 Feb;28(1):10-4.)
  40. Aspartame ingestion and headaches: a randomized crossover trial.(Neurology. 1994 Oct;44(10):1787-93.)
  41. Aspartame sensitivity? A double blind randomised crossover study.(PLoS One. 2015 Mar 18;10(3):e0116212.)

今話題の歯茎健康法『オイルプリング』って何??

  1. Fatty Acids and Derivatives as Antimicrobial Agents(Antimicrob Agents Chemother. 1972 Jul; 2(1): 23–28.)

  2. Antimicrobial Effects of Corn Zein Films Impregnated with Nisin, Lauric Acid, and EDTA(Journal of Food Protection®, Number 6, June 2001, pp. 759-906)

  3. Effect of oil pulling on Streptococcus mutans count in plaque and saliva using Dentocult SM Strip mutans test: A randomized, controlled, triple-blind study(Journal of Indian Society of Pedodontics and Preventive Dentistry 2008, 26: 1; 12-17)
  4. Effect of oil pulling on plaque induced gingivitis: A randomized, controlled, triple-blind study(Indian Journal of Dental Research 2009, 20: 1; 47-51)
  5. Effect of oil pulling on halitosis and microorganisms causing halitosis: A randomized controlled pilot trial(Journal of Indian Society of Pedodontics and Preventive Dentistry2011, 29: 2; 90-94)
  6. Systemic Toxicity Following Ingestion of the Chlorhexidine Gluconate Solution:A Case Report.(J. Intern. Acad. Period., 8/2:45-46, 2006.)
  7. Anaphylaxis to chlorhexidine digluconate(Journal of Healthcare-associated Infection (2009), 2, 18-19)

歯科衛生師さんに見て欲しい『SRPはどこまでが限界??』

  1. Role of “diseased” root cementum in healing following treatment of periodontal disease. A clinical study(J Clin Periodontal. 1988; 15:464-468)
  2. Healing of the dent-epithelial junction following sub gingival plaque control. 2:As observed on extracted teeth (J Periodontal. 1978; 49: 119-134)
  3. A systematic review of efficiency of machine-driven and manual subgingival debridement in the treatment of chronic periodontitis(J Clin Periodontal. 2002; 29: supply. 3:72-81)
  4. The distribution of bacterial lipopolysaccharide(endotoxin) in relation to periodontally involved root surfaces(J Clin Periodontal. 1986; 13: 748-751)

『乳製品』はガンの原因となる?それとも防ぐ?を大解剖!

  1. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.(Int J Cancer. 2010 Dec 15;127(12):2893-917.)
  2. Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies.(Ann Oncol. 2012 Jan;23(1):37-45.)
  3. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies.(Nutr Cancer. 2009;61(1):47-69.)
  4. Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies.(Nutr Cancer. 2009;61(1):47-69.)
  5. Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studies.(J Natl Cancer Inst. 2004 Jul 7;96(13):1015-22.)
  6. Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis.(Clin Ther. 2010 May;32(5):789-803.)
  7. Calcium and dairy food intakes are inversely associated with colorectal cancer risk in the Cohort of Swedish Men.(Am J Clin Nutr. 2006 Mar;83(3):667-73;)
  8. Vitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial.(J Natl Cancer Inst. 2003 Dec 3;95(23):1765-71.)
  9. Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study.(BMJ. 2010 Jan 21;340:b5500.)
  10. Dairy products and colorectal cancer. A review of possible mechanisms and epidemiological evidence.(Eur J Clin Nutr. 2003 Jan;57(1):1-17.)
  11. Dairy products, calcium, and prostate cancer risk: a systematic review and meta-analysis of cohort studies.(Am J Clin Nutr. 2015 Jan;101(1):87-117.)
  12. Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis.(J Natl Cancer Inst. 2005 Dec 7;97(23):1768-77.)
  13. Milk consumption is a risk factor for prostate cancer: meta-analysis of case-control studies.(Nutr Cancer. 2004;48(1):22-7.)
  14. Milk intake in early life and risk of advanced prostate cancer.(Am J Epidemiol. 2012 Jan 15;175(2):144-53.)
  15. Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition.(Br J Cancer. 2008 May 6;98(9):1574-81.)
  16. Risk of prostate cancer in a randomized clinical trial of calcium supplementation.(Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):586-9.)
  17. Dairy product consumption and the risk of prostate cancer(International Dairy JournalVolume 19, Issue 10, October 2009, Pages 551–565)
  18. Insulin-like growth factor-I and prostate cancer: a meta-analysis.(Br J Cancer. 2001 Sep 28;85(7):991-6.)
  19. Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.(Br J Cancer. 2003 Jun 2;88(11):1682-6.)
  20. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis.(Lancet. 2004 Apr 24;363(9418):1346-53.)
  21. Insulin-like growth factors and their binding proteins in prostate cancer: cause or consequence?(Urol Oncol. 2006 Jul-Aug;24(4):294-306.)
  22. Estrogen: one of the risk factors in milk for prostate cancer.(Med Hypotheses. 2004;62(1):133-42.)
  23. Exposure to exogenous estrogen through intake of commercial milk produced from pregnant cows.(Pediatr Int. 2010 Feb;52(1):33-8.)
  24. Global cancer statistics, 2002.(CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108.)
  25. Association between dairy intake and gastric cancer: a meta-analysis of observational studies.(PLoS One. 2014 Jul 9;9(7):e101728.)
  26. Dairy consumption and gastric cancer risk: a meta-analysis of epidemiological studies.(Nutr Cancer. 2015;67(4):555-68.)
  27. Dairy product consumption and gastric cancer risk: a meta-analysis.(World J Gastroenterol. 2014 Nov 14;20(42):15879-98.)
  28. Cows’ milk fat components as potential anticarcinogenic agents.(J Nutr. 1997 Jun;127(6):1055-60.)
  29. Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.(PLoS One. 2012;7(3):e31892.)
  30. IGF-1 and IGF-1BP3 in gastric adenocarcinoma. Preliminary study.(Hepatogastroenterology. 2003 Jan-Feb;50(49):297-300.)
  31. Human carcinogenesis and bracken fern: a review of the evidence.(Curr Med Chem. 2002 Mar;9(6):675-86.)
  32. Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis.(Toxicol Sci. 2012 Mar;126(1):60-71.)
  33. Cancer statistics, 2010.(CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300.)
  34. Consumption of dairy products and the risk of breast cancer: a review of the literature.(Am J Clin Nutr. 2004 Jul;80(1):5-14.)
  35. Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies.(Int J Epidemiol. 2002 Feb;31(1):78-85.)
  36. Breast cancer and dietary patterns: a systematic review.(Nutr Rev. 2014 Jan;72(1):1-17.)
  37. Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies.(Breast Cancer Res Treat. 2011 May;127(1):23-31.)
  38. How sound is the science behind the dietary recommendations for dairy?(Am J Clin Nutr. 2014 May;99(5 Suppl):1217S-22S.)
  39. Meeting adequate intake for dietary calcium without dairy foods in adolescents aged 9 to 18 years (National Health and Nutrition Examination Survey 2001-2002).(J Am Diet Assoc. 2006 Nov;106(11):1759-65.)
  40. Nutrients from dairy foods are difficult to replace in diets of Americans: food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003-2006.(Nutr Res. 2011 Oct;31(10):759-65.)

医学的根拠に基づいた『アロエベラ』の8つの秘密!

  1. Evolutionary history and leaf succulence as explanations for medicinal use in aloes and the global popularity of Aloe vera(BMC Evol Biol. 2015; 15: 29.)
  2. Antibacterial activities and antioxidant capacity of Aloe vera(Org Med Chem Lett. 2013; 3: 5.)

  3. The efficacy of aloe vera used for burn wound healing: a systematic review.(Burns. 2007 Sep;33(6):713-8.)
  4. Aloe vera for treating acute and chronic wounds.(Cochrane Database Syst Rev. 2012 Feb 15;2)
  5. Preliminary Antiplaque Efficacy of Aloe Vera Mouthwash on 4 Day Plaque Re-Growth Model: Randomized Control Trial(Ethiop J Health Sci. 2014 Apr; 24(2): 139–144.)

  6. Effect of Aloe vera mouthwash on periodontal health: triple(Oral Health Dent Manag. 2014 Mar;13(1):14-9.)
  7. Aloe Vera in Dentistry(J Clin Diagn Res. 2014 Oct; 8(10): ZI01–ZI02.)

  8. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration.(J Altern Complement Med. 2013 May;19(5):429-34.)
  9. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis(Dent Res J (Isfahan). 2012 Jul-Aug; 9(4): 381–385.)

  10. Metabolism and pharmacokinetics of anthropoids.(Pharmacology. 1993 Oct;47 Suppl 1:86-97.)
  11. An evidence-based systematic review of Aloe vera by the natural standard research collaboration.(J Herb Pharmacother. 2007;7(3-4):279-323.)
  12. Barbaloin: A concise report of its pharmacological and analytical aspects(Asian Pac J Trop Biomed. 2012 Oct; 2(10): 835–838.)

  13. Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome.(Int J Clin Pract. 2006 Sep;60(9):1080-6. Epub 2006 Jun 2.)
  14. Herbal medicines for the management of irritable bowel syndrome: A comprehensive review(World J Gastroenterol. 2012 Feb 21; 18(7): 589–600.)

  15. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis(Volume 19,  Issue 7pages 739–747April 2004)
  16. Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo(Ann Dermatol. 2009 Feb; 21(1): 6–11.)

  17. In Vivo skin hydration and anti-erythema effects of Aloe veraAloe ferox and Aloe marlothii gel materials after single and multiple applications(Pharmacogn Mag. 2014 Apr-Jun; 10(Suppl 2): S392–S403.)

  18. Evaluation of the Nutritional and Metabolic Effects of Aloe vera.(Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.)
  19. Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes(Diabetes Care April 2003 vol. 26 no. 4 1277-1294)

  20. Attitudes and beliefs among Mexican Americans about type 2 diabetes.(J Health Care Poor Underserved. 2004 Nov;15(4):576-88.)
  21. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus.(Phytomedicine. 1996 Nov;3(3):241-3.)
  22. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide.(Phytomedicine. 1996 Nov;3(3):245-8.)
  23. The antidiabetic activity of aloes: preliminary clinical and experimental observations.(Horm Res. 1986;24(4):288-94.)
  24. Aloe-induced Toxic Hepatitis(J Korean Med Sci. 2010 Mar; 25(3): 492–495.)

『キシリトールの効果』について知っておくべき全てを大暴露

  1. Sugar Alcohols and Diabetes: A Review(CANADIAN JOURNAL OF DIABETES.(2002;26(4):356-362.)
  2. The pentose cycle and insulin release in mouse pancreatic islets(Biochem J. 1972 Feb; 126(3): 525–532.)
  3. THE UNIVERSITY OF SYDNEY website(http://www.glycemicindex.com/foodSearch.php?num=2481&ak=detail)
  4. THE UNIVERSITY OF SYDNEY website(http://www.glycemicindex.com/foodSearch.php)
  5. Effects of xylitol on blood glucose, glucose tolerance, serum insulin and lipid profile in a type 2 diabetes model of rats.(Ann Nutr Metab. 2012;61(1):57-64.)
  6. Effects of xylitol on metabolic parameters and visceral fat accumulation.(J Clin Biochem Nutr. 2011 Jul;49(1):1-7.)
  7. Effects of xylitol as a sugar substitute on diabetes-related parameters in nondiabetic rats.(J Med Food. 2011 May;14(5):505-11.)
  8. Policy on the Use of Xylitol(AMERICAN ACADEMY OF PEDIATRIC DENTISTRY)
  9. Acid production from Lycasin, maltitol, sorbitol and xylitol by oral streptococci and lactobacilli.(Acta Odontol Scand. 1977;35(5):257-63.)
  10. Xylitol, Mutans Streptococci, and Dental Plaque(ADR August 2009 vol. 21 no. 1 74-78)
  11. Effect of xylitol on cariogenic and beneficial oral streptococci: a randomized, double-blind crossover trial(Iran J Microbiol. 2012 Jun; 4(2): 75–81.)
  12. Xylitol and caries prevention–is it a magic bullet?(Br Dent J. 2003 Apr 26;194(8):429-36.)
  13. Peroral xylitol increases intestinal calcium absorption in the rat independently of vitamin D action.(Miner Electrolyte Metab. 1985;11(3):178-81.)
  14. Turku sugar studies XVIII. Incidence of dental caries in relation to 1-year consumption of xylitol chewing gum.(Acta Odontol Scand. 1975;33(5):269-78.)
  15. Sugar alcohol sweeteners as alternatives to sugar with special consideration of xylitol.(Med Princ Pract. 2011;20(4):303-20.)
  16. The rocky road of xylitol to its clinical application.(J Dent Res. 2000 Jun;79(6):1352-5.)
  17. Effect of Xylitol on Growth of Streptococcus pneumoniae in the Presence of Fructose and Sorbitol(Antimicrob Agents Chemother. 2001 Jan; 45(1): 166–169.)
  18. Xylitol chewing gum in prevention of acute otitis media: double blind randomised trial.(BMJ. 1996 Nov 9; 313(7066): 1180–1184.)
  19. Effect of dietary carbohydrates on the in vitro epithelial adhesion of Candida albicans, Candida tropicalis, and Candida krusei.(New Microbiol. 2000 Jan;23(1):63-71.)
  20. Effects of a long-term dietary xylitol supplementation on collagen content and fluorescence of the skin in aged rats.(Gerontology. 2005 May-Jun;51(3):166-9.)
  21. Effects of dietary xylitol on collagen content and glycosylation in healthy and diabetic rats.(Life Sci. 2000 Jun 8;67(3):283-90.)
  22. Increased bone volume and bone mineral content in xylitol-fed aged rats.(Gerontology. 2001 Nov-Dec;47(6):300-5.)
  23. Dietary xylitol supplementation prevents osteoporotic changes in streptozotocin-diabetic rats.(Metabolism. 1998 May;47(5):578-83.)
  24. Gut microflora interactions with xylitol in the mouse, rat and man.(Food Chem Toxicol. 1985 Nov;23(11):985-90.)
  25. Xylitol toxicosis in dogs.(Vet Clin North Am Small Anim Pract. 2012 Mar;42(2):307-12)
  26. New findings on the effects of xylitol ingestion in dogs(Veterinary Medicine December 2006:791-797)
  27. Long-term tolerance of healthy human subjects to high amounts of xylitol and fructose: general and biochemical findings.(Int Z Vitam Ernahrungsforsch Beih. 1976;15:92-104.)

『ココナッツオイル』が体に良い10個の理由!

  1. nutritiondata.self.com (URL:http://nutritiondata.self.com/facts/fats-and-oils/508/2)
  2. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease (First published January 13, 2010, doi: 10.3945/​ajcn.2009.27725)
  3. Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies. (Am J Clin Nutr August 1981 
    vol. 34 no. 8 1552-1561)
  4. Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: a clinical study in Kitava. (J Intern Med. 1993 Mar;233(3):269-75.)
  5. Thermic effect of medium-chain and long-chain triglycerides in man. (Am J Clin Nutr. 1986 Nov;44(5):630-4.)
  6. Postprandial thermogenesis in lean and obese subjects after meals supplemented with medium-chain and long-chain triglycerides. (Am J Clin Nutr. 1991 May;53(5):1130-3.)
  7. Twenty-four-hour energy expenditure and urinary catecholamines of humans consuming low-to-moderate amounts of medium-chain triglycerides: a dose-response study in a human respiratory chamber.(Eur J Clin Nutr. 1996 Mar;50(3):152-8.)
  8. Fatty Acids and Derivatives as Antimicrobial Agents (Antimicrob Agents Chemother. 1972 Jul; 2(1): 23–28.)

  9. Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus. (J Bacteriol. 2000 May;182(9):2668-71.)
  10. In vitro antimicrobial properties of coconut oil on Candida species in Ibadan, Nigeria. (J Med Food. 2007 Jun;10(2):384-7.)
  11. The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms. (Obesity (Silver Spring). 2007 Jan;15(1):182-7.)
  12. Covert manipulation of the ratio of medium- to long-chain triglycerides in isoenergetically dense diets: effect on food intake in ad libitum feeding men. (Int J Obes Relat Metab Disord. 1996 May;20(5):435-44.)
  13. Influence of medium-chain and long-chain triacylglycerols on the control of food intake in men. (Am J Clin Nutr. 1998 Aug;68(2):226-34.)
  14. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial (Neurology Volume 7, No. 6, p500–506, June 2008)

  15. Ketogenicity of soybean oil, coconut oil and their respective fatty acids for the chick. (J Nutr. 1977 Dec;107(12):2206-12.)
  16. Medium-chain triglyceride (MCT) ketogenic therapy. (Epilepsia. 2008 Nov;49 Suppl 8:33-6.)
  17. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials (Am J Clin Nutr May 2003 vol. 77 no. 5 1146-1155)
  18. Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. (Am J Clin Nutr May 1998 
    vol. 67 no. 5 828-836)
  19. Effects of dietary coconut oil on the biochemical and anthropometric profiles of women presenting abdominal obesity. (Lipids. 2009 Jul;44(7):593-601. doi: 10.1007/s11745-009-3306-6. Epub 2009 May 13.)
  20. Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. (Clin Biochem. 2004 Sep;37(9):830-5.)
  21. Influence of virgin coconut oil on blood coagulation factors, lipid levels and LDL oxidation in cholesterol fed Sprague–Dawley rats (e-spen journal February 2008Volume 3, Issue 1, Pages e1–e8)

  22. A randomized double-blind controlled trial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderate xerosis. (Dermatitis. 2004 Sep;15(3):109-16.)
  23. Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage. (J Cosmet Sci. 2003 Mar-Apr;54(2):175-92.)
  24. Potential of herbs in skin protection from ultraviolet radiation. (Pharmacogn Rev. 2011 Jul;5(10):164-73.)
  25. Effect of oil pulling on Streptococcus mutans count in plaque and saliva using Dentocult SM Strip mutans test: A randomized, controlled, triple-blind study (Journal of Indian Society of Pedodontics and Preventive Dentistry 2008  |  Volume : 26  |  Issue : 1  |  Page : 12-17)
  26. Effect of oil pulling on plaque induced gingivitis: A randomized, controlled, triple-blind study (Indian Journal of Dental Research 2009  |  Volume : 20  |  Issue : 1  |  Page : 47-51)
  27. Effect of oil pulling on halitosis and microorganisms causing halitosis: A randomized controlled pilot trial (Journal of Indian Society of Pedodontics and Preventive Dentistry 2011  |  Volume : 29  |  Issue : 2  |  Page : 90-94)
  28. Hypometabolism as a therapeutic target in Alzheimer’s disease (BMC Neurosci. 2008; 9(Suppl 2): S16.)

  29. Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. (Neurobiol Aging. 2004 Mar;25(3):311-4.)
  30. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multi center trial (Nutrition & Metabolism 2009, 6:31)

  31. Ketone Bodies as a Therapeutic for Alzheimer’s Disease (Neurotherapeutics Volume 5, Issue 3, July 2008, Pages 470–480)
  32. An Open-Label Pilot Study to Assess the Efficacy and Safety of Virgin Coconut Oil in Reducing Visceral Adiposity (Published online 2011 Mar 15.)

『チア シード』が健康に良い11個の理由!

  1. Phytochemical profile and nutraceutical potential of chia seeds (Salvia hispanica L.) by ultra high performance liquid chromatography.
  2. Chia seeds as a source of natural lipid antioxidants
  3. Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanica L.) seeds
  4. Surviving Antioxidant Supplements
  5. Oxidants, antioxidants, and the degenerative diseases of aging
  6. Antioxidants and aging.
  7. Physicochemical properties of a fibrous fraction from chia (Salvia hispanica L.)
  8. Gut flora in health and disease.
  9. Isolation and Characterization of Proteins from Chia Seeds (Salvia hispanica L.)
  10. Thermal and Physicochemical Properties and Nutritional Value of the Protein Fraction of Mexican Chia Seed (Salvia hispanica L.)
  11. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations
  12. The effects of consuming frequent, higher protein meals on appetite and satiety during weight loss in overweight/obese men.
  13. Chemical and Functional Properties of Chia Seed (Salvia hispanica L.) Gum
  14. Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial.
  15. Effect of glucomannan on obese patients: a clinical study.
  16. Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.)
  17. Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.)
  18. Chia seed does not promote weight loss or alter disease risk factors in overweight adults
  19. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation.
  20. Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3)?
  21. Effect of a dietary portfolio (nopal, soy, oat, chia seed and inulin) on lipoprotein subclasses and LDL-cholesterol in Mexican subjects with hypercholesterolemia
  22. Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma.
  23. Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats.
  24. Supplementation of Conventional Therapy With the Novel Grain Salba (Salvia hispanica L.) Improves Major and Emerging Cardiovascular Risk Factors in Type 2 Diabetes Results of a randomized controlled trial
  25. Omega 3 Chia seed loading as a means of carbohydrate loading.

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